Transcriptomics

Dataset Information

98

Renal Cell Carcinoma Differential Expression


ABSTRACT: We investigated the changes in gene expression accompanying the development and progression of kidney cancer using 31,500 element complementary DNA arrays. We measured expression profiles for paired neoplastic and non-cancerous renal epithelium samples from 37 individuals. Using an experimental design optimized for factoring out technological and biological noise, and an adapted statistical test, we find 1738 differentially expressed cDNAs with an expected number of 6 false positives. Functional annotation of these genes provided views of the changes in the activities of specific biological pathways in renal cancer. Cell adhesion, signal transduction, and nucleotide metabolism were among the biological processes with a large proportion of genes overexpressed in renal cell carcinoma. Downregulated pathways in the kidney tumor cells included small molecule transport, ion homeostasis, and oxygen and radical metabolism. Our expression profiling data uncover gene expression changes shared with other epithelial tumors, as well as a unique signature for renal cell carcinoma. Expression data for the differentially expressed cDNAs are available in the web supplement (http://www.dkfz-heidelberg.de/abt0840/whuber/rcc). Keywords = renal clear cell carcinoma, kidney

ORGANISM(S): Homo sapiens  

SUBMITTER: Holger Sueltmann   Wolfgang Huber  Bernhard Korn  Andreas Vente  Laszlo Fuzesi  Stefan Haas  Martin Vingron  Judith M Boer  Friederike Wilmer  Annemarie Poustka  Anja von Heydebreck 

PROVIDER: E-GEOD-3 | ArrayExpress | 2010-05-28

SECONDARY ACCESSION(S): GSE3PRJNA84759

REPOSITORIES: GEO, ArrayExpress

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Publications

Identification and classification of differentially expressed genes in renal cell carcinoma by expression profiling on a global human 31,500-element cDNA array.

Boer J M JM   Huber W K WK   Sültmann H H   Wilmer F F   von Heydebreck A A   Haas S S   Korn B B   Gunawan B B   Vente A A   Füzesi L L   Vingron M M   Poustka A A  

Genome Research 20011101 11


We investigated the changes in gene expression accompanying the development and progression of kidney cancer by use of 31,500-element complementary DNA arrays. We measured expression profiles for paired neoplastic and noncancerous renal epithelium samples from 37 individuals. Using an experimental design optimized for factoring out technological and biological noise, and an adapted statistical test, we found 1738 differentially expressed cDNAs with an expected number of six false positives. Func  ...[more]

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