Transcriptomics

Dataset Information

36

Gene expression profiling in the leukemic stem cell-enriched CD34+ fraction identifies target genes that predict prognosis in normal karyotype AML


ABSTRACT: Mononuclear cells from AML patients (n=46) were sorted into CD34+ and CD34- subfractions and genome-wide expression analysis was performed using Illumina BeadChip Arrays (HT12 v3). Of 2 AML samples only the CD34+ fraction could be analyzed. AML CD34+ and CD34- gene expression was compared to a large group of normal CD34+ bone marrow cells (n=31). Mononuclear cells from AML patients (n=46) were sorted into CD34+ (46) and CD34- (44) subfractions and genome-wide expression analysis was performed using Illumina BeadChip Arrays (HT12 v3). AML CD34+ and CD34- gene expression was compared to a large group of normal CD34+ bone marrow cells (n=31).

ORGANISM(S): Homo sapiens  

SUBMITTER: Hendrik J de Jonge   Andre Mulder  Annet Z Vos  Carolien M Woolthuis  Edo Vellenga  Jan J Schuringa  Gerwin Huls  JJ Schuringa  Karen van der Weide  Eveline S de Bont  Philip M Kluin  Eva van den Berg 

PROVIDER: E-GEOD-30029 | ArrayExpress | 2011-07-18

SECONDARY ACCESSION(S): GSE30029PRJNA144051

REPOSITORIES: GEO, ArrayExpress

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Publications

Gene expression profiling in the leukemic stem cell-enriched CD34+ fraction identifies target genes that predict prognosis in normal karyotype AML.

de Jonge H J M HJ   Woolthuis C M CM   Vos A Z AZ   Mulder A A   van den Berg E E   Kluin P M PM   van der Weide K K   de Bont E S J M ES   Huls G G   Vellenga E E   Schuringa J J JJ  

Leukemia 20110715 12


In order to identify acute myeloid leukemia (AML) CD34(+)-specific gene expression profiles, mononuclear cells from AML patients (n=46) were sorted into CD34(+) and CD34(-) subfractions, and genome-wide expression analysis was performed using Illumina BeadChip Arrays. AML CD34(+) and CD34(-) gene expression was compared with a large group of normal CD34(+) bone marrow (BM) cells (n=31). Unsupervised hierarchical clustering analysis showed that CD34(+) AML samples belonged to a distinct cluster c  ...[more]

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