Transcriptomics

Dataset Information

29

MiRNA expression in the spleen of C57BL mice, p53-knockout C57BL mice, and NO2-knockout C57BL mice.


ABSTRACT: The goal of the study is to assess whether inflammation-induced oxidative and nitrosative stress modulates miRNA expression in mouse model deficient in either p53 or NOS2 RNA was extracted from the spleen of C57BL mice (WT, NOS2 knockout, and p53 knockout) that were C. Parvum treated or saline control treated. 4 or 5 mice were utilized for each grouping.

ORGANISM(S): Mus musculus  

SUBMITTER: Ewy Mathe  Hussain Perwez   Mathe Ewy    

PROVIDER: E-GEOD-30218 | ArrayExpress| 2012-06-26

SECONDARY ACCESSION(S): GSE30218PRJNA143963

REPOSITORIES: GEO, ArrayExpress

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Publications

Inflammation regulates microRNA expression in cooperation with p53 and nitric oxide.

Mathé Ewy E   Nguyen Giang H GH   Funamizu Naotake N   He Peijun P   Moake Matthew M   Croce Carlo M CM   Hussain S Perwez SP  

International journal of cancer 20111101 3


microRNA (miRNA) are small non-coding RNA targeting mRNAs leading to their instability and diminished translation. Altered expression of miRNA is associated with cancer. Inflammation and nitric oxide modulates the development of lymphomas in p53 knockout mice and there exists a negative feedback loop between p53 and NOS2. Using a genetic strategy, we tested the hypothesis that inflammation-induced oxidative and nitrosative stress modulates miRNA expression in mouse model deficient in either p53  ...[more]

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