Transcriptomics

Dataset Information

3

HIV Infection and Antiretroviral Therapy Have Divergent Effects on Mitochondria in Adipose Tissue


ABSTRACT: Exploratory microarray analysis identified significant changes in gene expression in adipose tissue. These included changes in genes regulating lipid and steroid metabolic processes and electron carrier activity in HIV-infected patients receiving antiretroviral therapy (ART). Additional genes involved in metabolic processes and mitochondrial function were found to be up-regulated in the adipose tissue of HIV-positive patients compared with HIV-negative controls. To identify differential gene expression in different tissues (PBMC, muscle, adipose tissue) between HIV patient groups (HIV negative, HIV positive with ART, HIV positive without ART).

ORGANISM(S): Homo sapiens  

SUBMITTER: Joachim G Voss   Carol L Vinton  Jan M Orenstein  Zoila G Rangel  Jun Yang  Caryn G Morse  Robert L Danner  Elisabeth J Rushing  Carolea Logun  Richard A Lempicki  Peter J Munson  Joseph A Kovacs  Xiaojun Hu  Marinos C Dalakas  Goran Rakocevic  Charles Huber  Da W Huang  Mary McLaughlin 

PROVIDER: E-GEOD-30310 | ArrayExpress | 2011-07-07

SECONDARY ACCESSION(S): GSE30310PRJNA143573

REPOSITORIES: GEO, ArrayExpress

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