Transcriptomics

Dataset Information

2

Comparison of mRNA expression among rat hepatoma cell lines with different metastatic ability


ABSTRACT: To reduce cancer mortality, understanding of mechanisms of cancer metastasis is crucial. We have established 6 rat hepatocellular carcinoma (HCC) cell lines, which exhibit differing metastatic potential to the lung after inoculation into the tail veins of nude mice. Micorarray analysis of 4 kinds of HCC cells and rat normal liver tissue was performed to find a potent molecular target for prevention of cancer metastasis. By the microarray analysis, mRNA expression was compared among two low-metastatic rat HCC cell lines (C5F and C6) and two high-metastatic rat HCC cell lines (N1 and L2) as well as non-treated rat liver tissue (as a reference sample).

ORGANISM(S): Rattus norvegicus  

SUBMITTER: Kumiko Ogawa   Tomoyuki Shirai  Shugo Suzuki  Makoto Asamoto  Pornsiri Pitchakarn  Teera Chewonarin 

PROVIDER: E-GEOD-30469 | ArrayExpress | 2012-06-20

SECONDARY ACCESSION(S): GSE30469PRJNA143503

REPOSITORIES: GEO, ArrayExpress

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Publications

Silencing of connexin 43 suppresses invasion, migration and lung metastasis of rat hepatocellular carcinoma cells.

Ogawa Kumiko K   Pitchakarn Pornsiri P   Suzuki Shugo S   Chewonarin Teera T   Tang MingXi M   Takahashi Seishiro S   Naiki-Ito Aya A   Sato Shinya S   Takahashi Satoru S   Asamoto Makoto M   Shirai Tomoyuki T  

Cancer Science 20120328 5


To reduce cancer mortality, understanding of mechanisms of cancer metastasis is crucial. We have established six rat hepatocellular carcinoma (HCC) cell lines, which exhibit differing metastatic potential to the lung after inoculation into the tail veins of nude mice. In the present experiment, we investigated the process of cell attachment to metastatic sites and possible regulating factors. One hour after inoculation, two of two HCC cell lines with high metastatic potential and one of two HCC  ...[more]

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