Transcriptomics

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Derivation of Rhesus Monkey Parthenogenetic Embryonic Stem Cells and its MicroRNA Signature


ABSTRACT: We derived two novel rpESC lines and characterized their microRNA signature by Solexa deep sequencing. By characterizing their microRNA signature, we identified 91 novel microRNAs, except those are also detected in other primate ESCs. Moreover, these two novel rpESCs display a unique microRNA signature, comparing to their biparental counterpart ESCs. Examination of 2 different small RNA expression profilings in 2 rhesus parthenogenetic embryonic stem cell lines

ORGANISM(S): Macaca mulatta  

SUBMITTER: zhenghua sun   Zhenghua Sun 

PROVIDER: E-GEOD-30510 | ArrayExpress | 2011-10-18

SECONDARY ACCESSION(S): GSE30510SRP007422PRJNA143329

REPOSITORIES: GEO, ArrayExpress, ENA

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Publications

Derivation of rhesus monkey parthenogenetic embryonic stem cells and its microRNA signature.

Wei Qiang Q   Sun Zhenghua Z   He Xiechao X   Tan Tao T   Lu Bin B   Guo Xiangyu X   Su Bing B   Ji Weizhi W  

PloS one 20110926 9


Parthenogenetic embryonic stem cells are considered as a promising resource for regeneration medicine and powerful tools for developmental biology. A lot of studies have revealed that embryonic stem cells have distinct microRNA expression pattern and these microRNAs play important roles in self-renewal and pluripotency of embryonic stem cells. However, few studies concern about microRNA expression pattern in parthenogenetic embryonic stem cells, especially in non-human primate--the ideal model s  ...[more]

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