Transcriptomics

Dataset Information

3

The PII protein GlnK is a pleiotropic regulator for morphological differentiation and secondary metabolism in Streptomyces coelicolor


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE30569: Metabolic switching in Streptomyces coelicolor wild type, time series under glutamate depletion condition GSE30570: Metabolic switching in Streptomyces coelicolor time series under glutamate depletion of mutant SCglnK-3. Refer to individual Series

ORGANISM(S): Streptomyces coelicolor  

SUBMITTER: Alexander Wentzel   Stream Consortium  Wolfgang Wohlleben  Kay Nieselt 

PROVIDER: E-GEOD-30571 | ArrayExpress | 2011-12-31

SECONDARY ACCESSION(S): GSE30571PRJNA143365

REPOSITORIES: GEO, ArrayExpress

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Publications

The PII protein GlnK is a pleiotropic regulator for morphological differentiation and secondary metabolism in Streptomyces coelicolor.

Waldvogel Eva E   Herbig Alexander A   Battke Florian F   Amin Rafat R   Nentwich Merle M   Nieselt Kay K   Ellingsen Trond E TE   Wentzel Alexander A   Hodgson David A DA   Wohlleben Wolfgang W   Mast Yvonne Y  

Applied microbiology and biotechnology 20111028 6


GlnK is an important nitrogen sensor protein in Streptomyces coelicolor. Deletion of glnK results in a medium-dependent failure of aerial mycelium and spore formation and loss of antibiotic production. Thus, GlnK is not only a regulator of nitrogen metabolism but also of morphological differentiation and secondary metabolite production. Through a comparative transcriptomic approach between the S. coelicolor wild-type and a S. coelicolor glnK mutant strain, 142 genes were identified that are diff  ...[more]

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