Transcriptomics

Dataset Information

4

Gene expression profile in the diaphragm following contractile inactivity during thoracic surgery


ABSTRACT: Recent work revealed the development of marked diaphragm muscle fiber weakness during two hours of thoracic surgery. This loss of muscle fiber function was not part of a generalized muscle weakness as function of the non-respiratory latissimus dorsi muscle was preserved. To disentangle the molecular processes that might underlie the development of diaphragm muscle fiber weakness during thoracic surgery we studied changes in the gene expression profile. Analyzed were diaphragm samples at t0 vs t2 and latissimus dorsi at t0 vs t2. In total 8 Diaphragm samples and 6 latissimus dorsi samples were analyzed.

ORGANISM(S): Homo sapiens  

SUBMITTER: Daoud Sie   Coen A Ottenheijm 

PROVIDER: E-GEOD-30658 | ArrayExpress | 2013-07-03

SECONDARY ACCESSION(S): GSE30658PRJNA144609

REPOSITORIES: GEO, ArrayExpress

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Publications

Gene expression profile in the diaphragm following contractile inactivity during thoracic surgery.

Welvaart Willem N WN   Paul Marinus A MA   Kuster Diederik Wd DW   van Wieringen Wesseln W   Rustenburg Francois F   Stienen Ger Jm GJ   Vonk-Noordegraaf Anton A   Ottenheijm Coen Ac CA  

International journal of physiology, pathophysiology and pharmacology 20110907 3


Introduction. Recent work revealed the development of marked muscle fiber weakness in the diaphragm, but not in the non-respiratory latissimus dorsi, during thoracic surgery. To disentangle the molecular processes that underlie the development of diaphragm muscle fiber weakness during thoracic surgery, we studied changes in the gene expression profile. Methods. Serial biopsies from the diaphragm and the latissimus dorsi muscle were obtained from four patients during thoracotomy for resection of  ...[more]

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