Dataset Information


Viral microRNA expression in two nasal NK T cell lymphoma cell lines

ABSTRACT: We have used microarray profiling to examine the expression of viral microRNAs (miRNAs) in two independently derived nasal natural killer T cell lymphoma (NKTCL) cell lines, SNK6 and SNT16. The goal of the study was to investigate the role of the viral miRNAs in the genesis and maintenance of NKTCLs. This experiment includes a total of 2 samples, one from SNK6 cells and the other from SNT16 cells.

ORGANISM(S): Homo sapiens  

SUBMITTER: Paul D Ling   Rajesh Ramakrishnan 

PROVIDER: E-GEOD-30695 | ArrayExpress | 2011-11-28



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Epstein-Barr virus BART9 miRNA modulates LMP1 levels and affects growth rate of nasal NK T cell lymphomas.

Ramakrishnan Rajesh R   Donahue Hart H   Garcia David D   Tan Jie J   Shimizu Norio N   Rice Andrew P AP   Ling Paul D PD  

PloS one 20111110 11

Nasal NK/T cell lymphomas (NKTCL) are a subset of aggressive Epstein-Barr virus (EBV)-associated non-Hodgkin's lymphomas. The role of EBV in pathogenesis of NKTCL is not clear. Intriguingly, EBV encodes more than 40 microRNAs (miRNA) that are differentially expressed and largely conserved in lymphocryptoviruses. While miRNAs play a critical role in the pathogenesis of cancer, especially lymphomas, the expression and function of EBV transcribed miRNAs in NKTCL are not known. To examine the role o  ...[more]

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