Transcriptomics,Multiomics

Dataset Information

5

CDK8 knockdown in HT-29 cells and CDK8 & MED12 knockdown in R1 cells


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE30815: CDK8 knockdown in HT-29 human colon cancer cells GSE30816: CDK8 and MED12 knockdown in R1 mouse ES cells Refer to individual Series

OTHER RELATED OMICS DATASETS IN: PRJNA154571PRJNA154569PRJNA144197

ORGANISM(S): Musculus  

SUBMITTER: Zora Modrusan   Adam S Adler 

PROVIDER: E-GEOD-30817 | ArrayExpress | 2012-03-05

SECONDARY ACCESSION(S): GSE30817PRJNA144197

REPOSITORIES: GEO, ArrayExpress

Dataset's files

Source:
Action DRS
E-GEOD-30817.README.txt Txt
E-GEOD-30817.idf.txt Idf
E-GEOD-30817.processed.1.zip Processed
E-GEOD-30817.raw.1.zip Raw
E-GEOD-30817.raw.2.zip Raw
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Publications

CDK8 maintains tumor dedifferentiation and embryonic stem cell pluripotency.

Adler Adam S AS   McCleland Mark L ML   Truong Tom T   Lau Shari S   Modrusan Zora Z   Soukup Tim M TM   Roose-Girma Merone M   Blackwood Elizabeth M EM   Firestein Ron R  

Cancer research 20120216 8


CDK8 is a cyclin-dependent kinase that mediates transcriptional control of pathways linked to both cancer and stem cells. In this study, we show that CDK8 is required for both tumor growth and maintenance of tumor dedifferentiation in vivo and uncover a common role for CDK8 in controlling cancer and stem cell function. Acute CDK8 loss in vivo strongly inhibited tumor growth and promoted differentiation. Transcriptional profiling identified a set of embryonic stem cell-related genes that are acti  ...[more]

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