Dataset Information


Genome-wide maps of histone modifications unwind in vivo chromatin states of the hair follicle lineage [ChIP-Seq]

ABSTRACT: Mouse hair follicles undergo synchronized cycles. Cyclical regeneration and hair growth is fueled by stem cells (SCs). During the rest phase, the HF-SCs remain quiescent due to extrinsic inhibitory signals within the niche. As activating cues accumulate, HF-SCs become activated, proliferate, and grows downward to form transient-amplifying matrix progenitor cells. We used ChIP-seq to reveal the genome-wide maps of histone modifications underlying the states of hair follicle stem cells and their transient-amplifying progeny before differentiation. Quiescent hair follicle stem cells (qHF-SCs), activated hair follicle stem cells (aHF-SCs) and transient-amplifying matrix cells (HF-TACs) were FACS-purified for ChIP-sequcencing.

ORGANISM(S): Mus musculus  

SUBMITTER: Elaine Fuchs   Wen-Hui Lien 

PROVIDER: E-GEOD-31239 | ArrayExpress | 2011-09-02



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Genome-wide maps of histone modifications unwind in vivo chromatin states of the hair follicle lineage.

Lien Wen-Hui WH   Guo Xingyi X   Polak Lisa L   Lawton Lee N LN   Young Richard A RA   Zheng Deyou D   Fuchs Elaine E  

Cell stem cell 20110901 3

Using mouse skin, where bountiful reservoirs of synchronized hair follicle stem cells (HF-SCs) fuel cycles of regeneration, we explore how adult SCs remodel chromatin in response to activating cues. By profiling global mRNA and chromatin changes in quiescent and activated HF-SCs and their committed, transit-amplifying (TA) progeny, we show that polycomb-group (PcG)-mediated H3K27-trimethylation features prominently in HF-lineage progression by mechanisms distinct from embryonic-SCs. In HF-SCs, P  ...[more]

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