Transcriptomics

Dataset Information

6

Expression data from SP and non-SP sorted anti-EpCAM treated A2C12 cells


ABSTRACT: Targeted therapies against cancer stem cells which are enriched in side populations (SP) involves interruption of Wnt-signalling. Furthermore, EpCAM is a SP marker and modulator of Wnt-signalling. Therefore, the effects of an anti-EpCAM treatment on SP-cells and WNT/β-catenin signalling was studied. SP of the murine lung adenocarcinoma cell line A2C12 was obtained by fluorescence activated cell sorting and whole genome scans helped to define their molecular phenotype after anti-EpCAM antibody treatment. Anti-EpCAM treated and untreated A2C12 cells were subjected to Hoechst 33342 dye exclusion assay and sorted to SP and non-SP fractions by FACS. Three biological replicates.

ORGANISM(S): Mus musculus  

SUBMITTER: Astrid Rohrbeck   Thomas Krüwel 

PROVIDER: E-GEOD-31246 | ArrayExpress | 2012-08-07

SECONDARY ACCESSION(S): GSE31246PRJNA154111

REPOSITORIES: GEO, ArrayExpress

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