Transcriptomics

Dataset Information

3

Macrophage response to lipopolysaccharide


ABSTRACT: Temporal analysis of bone marrow derived macrophages after 10 ug/ml lipopolysaccharide stimulation. C57BL6, C3H/ARC, BalbC and C3H/HeJ mouse strains analyzed. Each time point stimulated with 10ug/ml LPS from Salmonella minnesota for the time indicated. The RNA from each BMM stimulated time point was labeled with Cy3 and compared with a common reference (total RNA from C57BL6/J 17.5 embryo) labeled with Cy5.

ORGANISM(S): Mus musculus  

SUBMITTER: David Hume  Christine A Wells  Yashushi Okazaki  Geoff Faulkner  Timothy Ravasi  Matthew Sweet  Yoshihide Hayashizaki  Brandon Wainwright  Piero Carninci 

PROVIDER: E-GEOD-3148 | ArrayExpress | 2010-07-01

SECONDARY ACCESSION(S): GSE3148PRJNA92977

REPOSITORIES: GEO, ArrayExpress

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Publications

Continued discovery of transcriptional units expressed in cells of the mouse mononuclear phagocyte lineage.

Wells Christine A CA   Ravasi Timothy T   Sultana Razvan R   Yagi Ken K   Carninci Piero P   Bono Hidemasa H   Faulkner Geoffrey G   Okazaki Yasushi Y   Quackenbush John J   Hume David A DA   Lyons Paul A PA  

Genome research 20030601 6B


The current RIKEN transcript set represents a significant proportion of the mouse transcriptome but transcripts expressed in the innate and acquired immune systems are poorly represented. In the present study we have assessed the complexity of the transcriptome expressed in mouse macrophages before and after treatment with lipopolysaccharide, a global regulator of macrophage gene expression, using existing RIKEN 19K arrays. By comparison to array profiles of other cells and tissues, we identify  ...[more]

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