Dataset Information


Genome-wide analysis of STAT3-binding and gene expression changes in peritoneal macrophages upon interleukin-10 stimulation

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE31529: Genome-wide binding of STAT3 in peritoneal macrophages GSE31530: Transcriptome changes in IL-10 treated peritoneal macrophages Refer to individual Series

ORGANISM(S): Mus musculus  

SUBMITTER: Diego Miranda-Saavedra   Andrew Paul Hutchins  Andrew P Hutchins 

PROVIDER: E-GEOD-31531 | ArrayExpress | 2012-02-13



altmetric image


Genome-wide analysis of STAT3 binding in vivo predicts effectors of the anti-inflammatory response in macrophages.

Hutchins Andrew Paul AP   Poulain Stéphane S   Miranda-Saavedra Diego D  

Blood 20120209 13

Inflammation is a powerful response of the immune system against invading pathogens, and must be cancelled when unneeded or otherwise death inevitably follows. In macrophages, the anti-inflammatory response (AIR) is driven by STAT3 upon IL-10 signaling. The role of STAT3 is to stimulate the expression of specific genes that in-turn suppress the transcription of proinflammatory genes. Here we describe a systematic approach to identify the elusive STAT3-controlled effectors of the AIR. In vivo STA  ...[more]

Similar Datasets

2012-02-13 | E-GEOD-31529 | ArrayExpress
2012-02-13 | E-GEOD-31530 | ArrayExpress
2013-03-22 | E-GEOD-45382 | ArrayExpress
2012-08-20 | E-GEOD-34811 | ArrayExpress
2012-08-07 | E-GEOD-35047 | ArrayExpress
2011-07-30 | E-MEXP-3189 | ArrayExpress
2014-09-17 | E-GEOD-53101 | ArrayExpress
2011-12-13 | E-GEOD-33721 | ArrayExpress
2013-04-09 | E-GEOD-43075 | ArrayExpress
2011-10-04 | E-GEOD-32621 | ArrayExpress