Dataset Information


ChIP-Seq of ORC2 bound to third instar salivary gland DNA in WT and mutant Drosophila, analyzed by Illumina sequencing

ABSTRACT: We analyzed ORC2 ChIP-Seq from hand dissected salivary glands of wandering third instar larvae from OrR or SuUR Drosophila. Goals were to ascertain the difference in binding profile between salivary glands expressing and not expressing the Supressor of UnderReplication protein. One replicate is included for each of OrR (WT) or SuUR salivary glands.

ORGANISM(S): Drosophila melanogaster  

SUBMITTER: Terry L Orr-Weaver   Noa Sher  Terry L. Orr-Weaver 

PROVIDER: E-GEOD-31899 | ArrayExpress | 2011-10-18



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Developmental control of gene copy number by repression of replication initiation and fork progression.

Sher Noa N   Bell George W GW   Li Sharon S   Nordman Jared J   Eng Thomas T   Eaton Matthew L ML   Macalpine David M DM   Orr-Weaver Terry L TL  

Genome research 20111116 1

Precise DNA replication is crucial for genome maintenance, yet this process has been inherently difficult to study on a genome-wide level in untransformed differentiated metazoan cells. To determine how metazoan DNA replication can be repressed, we examined regions selectively under-replicated in Drosophila polytene salivary glands, and found they are transcriptionally silent and enriched for the repressive H3K27me3 mark. In the first genome-wide analysis of binding of the origin recognition com  ...[more]

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