Transcriptomics

Dataset Information

4

Profiling whole lung from Ovalbumin (OVA)-challenged and control BALB/c mice


ABSTRACT: This program aims at identifying the lung gene signature associated with OVA-challenged mouse asthma model to facilitate understanding of the disease mechanism and therapeutic compound testing The OVA-challenged profiling data was analyzed by identifying genes that were up- and down-regulated at selected p value and fold change in the lungs of OVA-challenged mice compared to the corresponding PBS-treated controls.

ORGANISM(S): Mus musculus  

SUBMITTER: I-Ming Wang   Bin Zhang 

PROVIDER: E-GEOD-31949 | ArrayExpress | 2013-03-22

SECONDARY ACCESSION(S): GSE31949PRJNA155287

REPOSITORIES: GEO, ArrayExpress

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Publications


Common inflammatome gene signatures as well as disease-specific signatures were identified by analyzing 12 expression profiling data sets derived from 9 different tissues isolated from 11 rodent inflammatory disease models. The inflammatome signature significantly overlaps with known drug targets and co-expressed gene modules linked to metabolic disorders and cancer. A large proportion of genes in this signature are tightly connected in tissue-specific Bayesian networks (BNs) built from multiple  ...[more]

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