Transcriptomics

Dataset Information

63

Jarid1b targets genes regulating development and is involved in neural differentiation [expression array]


ABSTRACT: The H3K4me2/3 histone demethylase Jarid1b (Kdm5b/Plu1) is dispensable for embryonic stem cell (ESC) self-renewal, but essential for ESC differentiation along the neural lineage. During neural differentiation, Jarid1b depleted ESCs fail to efficiently silence lineage-inappropriate genes, specifically stem and germ cell genes. Our results delineate an essential role for Jarid1b-mediated transcriptional control during ESC differentiation. Control (LKOScr) or Jarid1b knockdown (LKOJarid1b) mouse ES cells were used.Each experiment was performed in triplicates.

ORGANISM(S): Mus musculus  

SUBMITTER: Sandra Ursula Schmitz  

PROVIDER: E-GEOD-31967 | ArrayExpress | 2011-10-26

SECONDARY ACCESSION(S): GSE31967PRJNA155271

REPOSITORIES: GEO, ArrayExpress

altmetric image

Publications

Jarid1b targets genes regulating development and is involved in neural differentiation.

Schmitz Sandra U SU   Albert Mareike M   Malatesta Martina M   Morey Lluis L   Johansen Jens V JV   Bak Mads M   Tommerup Niels N   Abarrategui Iratxe I   Helin Kristian K  

The EMBO journal 20111101 22


H3K4 methylation is associated with active transcription and in combination with H3K27me3 thought to keep genes regulating development in a poised state. The contribution of enzymes regulating trimethylation of lysine 4 at histone 3 (H3K4me3) levels to embryonic stem cell (ESC) self-renewal and differentiation is just starting to emerge. Here, we show that the H3K4me2/3 histone demethylase Jarid1b (Kdm5b/Plu1) is dispensable for ESC self-renewal, but essential for ESC differentiation along the n  ...[more]

Similar Datasets

2011-10-26 | E-GEOD-31968 | ArrayExpress
2011-10-26 | E-GEOD-31966 | ArrayExpress
2014-05-19 | E-GEOD-50479 | ArrayExpress
2013-01-31 | E-GEOD-43920 | ArrayExpress
2011-04-13 | E-GEOD-24842 | ArrayExpress
2015-09-03 | E-GEOD-16364 | ExpressionAtlas
2013-04-26 | E-GEOD-41172 | ArrayExpress
2010-02-22 | E-GEOD-16364 | ArrayExpress
2013-04-26 | E-GEOD-41171 | ArrayExpress
2011-06-18 | E-TABM-1121 | ArrayExpress