Transcriptomics,Genomics

Dataset Information

62

Jarid1b targets genes regulating development and is involved in neural differentiation


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE31966: Jarid1b targets genes regulating development and is involved in neural differentiation [ChIP-seq] GSE31967: Jarid1b targets genes regulating development and is involved in neural differentiation [expression array] Refer to individual Series

ORGANISM(S): Mus musculus  

SUBMITTER: Sandra Ursula Schmitz  

PROVIDER: E-GEOD-31968 | ArrayExpress | 2011-10-26

SECONDARY ACCESSION(S): GSE31968PRJNA144987

REPOSITORIES: GEO, ArrayExpress

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Publications

Jarid1b targets genes regulating development and is involved in neural differentiation.

Schmitz Sandra U SU   Albert Mareike M   Malatesta Martina M   Morey Lluis L   Johansen Jens V JV   Bak Mads M   Tommerup Niels N   Abarrategui Iratxe I   Helin Kristian K  

The EMBO journal 20111101 22


H3K4 methylation is associated with active transcription and in combination with H3K27me3 thought to keep genes regulating development in a poised state. The contribution of enzymes regulating trimethylation of lysine 4 at histone 3 (H3K4me3) levels to embryonic stem cell (ESC) self-renewal and differentiation is just starting to emerge. Here, we show that the H3K4me2/3 histone demethylase Jarid1b (Kdm5b/Plu1) is dispensable for ESC self-renewal, but essential for ESC differentiation along the n  ...[more]

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