Dataset Information


Comparison of transcriptomes between Marf1+/+ (WT) and Marf1 ENU/ENU (Mutant) fully-grown oocytes (FGO)

ABSTRACT: Marf1 (MUT) female mice are infertile and the meiosis of the oocytes are arrest at prophase I. We thought to identify the potential causes of the meiotic arrest phenotype in the mutant oocytes by comparing the transcriptomes of the WT and mutant fully-grown oocytes (from 23-d old mice) that are transcriptional silent. We compared the transcriptomes of WT and MUT FGOs. 3 individual oocyte samples of each genotype (WT and MUT).

ORGANISM(S): Mus musculus  

SUBMITTER: John Eppig   You-Qiang Su 

PROVIDER: E-GEOD-31985 | ArrayExpress | 2012-03-30



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MARF1 regulates essential oogenic processes in mice.

Su You-Qiang YQ   Sugiura Koji K   Sun Fengyun F   Pendola Janice K JK   Cox Gregory A GA   Handel Mary Ann MA   Schimenti John C JC   Eppig John J JJ  

Science (New York, N.Y.) 20120301 6075

Development of fertilization-competent oocytes depends on integrated processes controlling meiosis, cytoplasmic development, and maintenance of genomic integrity. We show that meiosis arrest female 1 (MARF1) is required for these processes in mammalian oocytes. Mutations of Marf1 cause female infertility characterized by up-regulation of a cohort of transcripts, increased retrotransposon expression, defective cytoplasmic maturation, and meiotic arrest. Up-regulation of protein phosphatase 2 cata  ...[more]

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