Transcriptomics

Dataset Information

3

Role of SIRT1 in human hepatocellular carcinoma


ABSTRACT: To investigate the specific roles of SIRT1 in the development of hepatocellular carcinoma, we employed large-scale gene expression analysis to identify the molecular signature that may affect enabling characteristics of cancer cells. Differentially expressed genes were analyzed on the SNU-182 cells transfected with SIRT1 siRNA and recapitulated molecular signatures that related to hallmarks of cancer. SIRT1 expression in hepatocellular carcinoma was analyzed by RT-PCR and western blot. RNA interference-mediated protein knockdown method was used to investigate oncogenic potential of SIRT1 in hepatocelluar carcinoma

ORGANISM(S): Homo sapiens  

SUBMITTER: JUNGWOO EUN   Kwang-Hwa Jung  Hyun-Jin Bae  Jung-Woo Eun  Young-Gyoon Chang  Suk-Woo Nam  Ji-Heon Noh  Won-Sang Park  Min-Gyu Kim  Jung-Young Lee  Jeong-Kyu Kim  Hong-Jian Xie 

PROVIDER: E-GEOD-32066 | ArrayExpress | 2012-03-01

SECONDARY ACCESSION(S): GSE32066PRJNA147605

REPOSITORIES: GEO, ArrayExpress

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