Transcriptomics

Dataset Information

4

WTAP-induced change in gene expresssion in cholangiocarcinoma cells


ABSTRACT: Knock-down or overexpression of WTAP regulated migration and invasion of cholangiocarcinoma cells in vivo and vitro studies. To investigate the underlying mechanism for WTAP-regulated migration and invasion, the gene expression between the mock cells and the stable cells was compared Total RNA was purified from the mock cells and the stable cells overexpressing WTAP

ORGANISM(S): Homo sapiens  

SUBMITTER: Sae-Ock Oh   Seon-Young Kim 

PROVIDER: E-GEOD-32134 | ArrayExpress | 2015-04-06

SECONDARY ACCESSION(S): GSE32134PRJNA147665

REPOSITORIES: GEO, ArrayExpress

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Publications

WTAP regulates migration and invasion of cholangiocarcinoma cells.

Jo Hong-Jae HJ   Shim Hye-Eun HE   Han Myoung-Eun ME   Kim Hyun-Jung HJ   Kim Ki-Sun KS   Baek Sungmin S   Choi Kyung-Un KU   Hur Gi-Yeong GY   Oh Sae-Ock SO  

Journal of gastroenterology 20130125 11


Wilms' tumor 1-associating protein (WTAP) is a nuclear protein that has been associated with the regulation of proliferation and apoptosis. Although its dynamic expression and physiological functions in vascular cells have been reported, its expression and roles in cholangiocarcinoma cells are poorly characterized.To examine the expression of WTAP in patient tissues, we performed immunohistochemistry. To examine motility of cholangiocarcinoma cells, we employed Boyden chamber, wound healing and  ...[more]

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