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MiR-34a is downregulated in cis-diamminedichloroplatinum treated sinonasal squamous cell carcinoma patients with poor prognosis.

ABSTRACT: For the purpose of analyzing mechanisms related to the cis-diamminedichloroplatinum (CDDP) resistance in head and neck squamous cell carcinoma (head and neck SCC), we employed a nasal squamous cell carcinoma (nasal SCC) cell line RPMI2650 and its CDDP resistant substrain RPMI2650CR previously described. The identification of the resistance-related microRNA (miR) clusters was conducted between RPMI2650CR and RPMI2650 using microRNA microarray. microRNA expression of parental and CDDP resistant was measured with or without CDDP treatment in duplicate.

ORGANISM(S): Homo sapiens

SUBMITTER: yuriko saiki Akira Horii Yuriko Saiki Takenori Ogawa

PROVIDER: E-GEOD-32176 | ArrayExpress | 2012-06-13

SECONDARY ACCESSION(S): GSE32176PRJNA147413

REPOSITORIES: GEO, ArrayExpress

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miR-34a is downregulated in cis-diamminedichloroplatinum treated sinonasal squamous cell carcinoma patients with poor prognosis.

Ogawa Takenori T Saiki Yuriko Y Shiga Kiyoto K Chen Na N Fukushige Shinichi S Sunamura Makoto M Nagase Hiroki H Hashimoto Sho S Matsuura Kazuto K Saijo Shigeru S Kobayashi Toshimitsu T Horii Akira A

Cancer science 20120706 9

For the purpose of analyzing mechanisms related to the cis-diamminedichloroplatinum resistance in head and neck squamous cell carcinoma, we analyzed RPMI2650 and its derived previously established cis-diamminedichloroplatinum resistant cell line RPMI2650CR. To identify resistant phenotype-related microRNAs, we compared microRNA expressions between RPMI2650CR and RPMI2650 by microarray. One of the microRNAs as downregulated, miR-34a, was further investigated. Decreased expression of miR-34a in RP ...[more]

PMID: 22624980

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