Transcriptomics

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MiR-34a is downregulated in cis-diamminedichloroplatinum treated sinonasal squamous cell carcinoma patients with poor prognosis.

ABSTRACT: For the purpose of analyzing mechanisms related to the cis-diamminedichloroplatinum (CDDP) resistance in head and neck squamous cell carcinoma (head and neck SCC), we employed a nasal squamous cell carcinoma (nasal SCC) cell line RPMI2650 and its CDDP resistant substrain RPMI2650CR previously described. The identification of the resistance-related microRNA (miR) clusters was conducted between RPMI2650CR and RPMI2650 using microRNA microarray. microRNA expression of parental and CDDP resistant was measured with or without CDDP treatment in duplicate.

ORGANISM(S): Homo sapiens  

SUBMITTER: yuriko saiki   Akira Horii  Yuriko Saiki  Takenori Ogawa 

PROVIDER: E-GEOD-32176 | ArrayExpress | 2012-06-13

SECONDARY ACCESSION(S): GSE32176PRJNA147413

REPOSITORIES: GEO, ArrayExpress

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miR-34a is downregulated in cis-diamminedichloroplatinum treated sinonasal squamous cell carcinoma patients with poor prognosis.

Ogawa Takenori T   Saiki Yuriko Y   Shiga Kiyoto K   Chen Na N   Fukushige Shinichi S   Sunamura Makoto M   Nagase Hiroki H   Hashimoto Sho S   Matsuura Kazuto K   Saijo Shigeru S   Kobayashi Toshimitsu T   Horii Akira A  

Cancer science 20120706 9

For the purpose of analyzing mechanisms related to the cis-diamminedichloroplatinum resistance in head and neck squamous cell carcinoma, we analyzed RPMI2650 and its derived previously established cis-diamminedichloroplatinum resistant cell line RPMI2650CR. To identify resistant phenotype-related microRNAs, we compared microRNA expressions between RPMI2650CR and RPMI2650 by microarray. One of the microRNAs as downregulated, miR-34a, was further investigated. Decreased expression of miR-34a in RP  ...[more]

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