Transcriptomics

Dataset Information

30

Expression data for primary localized prostate cancer versus castration-resistant bone metastatic prostate cancer


ABSTRACT: We compared 22 primary Pca (hormone-dependent) versus 29 metastatic Pca (CRPC). The expression of genes related to cell cycle, proliferation, DNA synthesis, and androgen metablism are significantly increased in CRPC group. The expression of AR-stimulated genes were partially reactivated. TMPRSS2-ERG fusion status was determined for the samples by PCR. The expression of ERG was highly increased in fusion positive versus negative. 120 snap-frozen CT-guided bone marrow biopsies from patients with castration-resistant prostate cancer were collected as a source of material. 29 independent biopsies containing mostly tumor were identified as CRPC group through carefully microscopical examination. 4 samples containing no tumor were identified as normal bone marrow group. Primary tumor was isolated by LCM from frozen biopsies of hormone-naive patients. 22 samples were selected as primary PCa group.

ORGANISM(S): Homo sapiens  

SUBMITTER: Phillip G Febbo  Changmeng Cai   Michael Stanbrough   Steven P Balk    

PROVIDER: E-GEOD-32269 | ArrayExpress| 2011-10-12

SECONDARY ACCESSION(S): GSE32269PRJNA147325

REPOSITORIES: GEO, ArrayExpress

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