Dataset Information


Expression and ChIP-seq analysis LPS stimulated THP-1 cells

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE32141: Expression analysis LPS stimulated THP-1 cells in four paired samples GSE32324: ChIP-seq analysis LPS stimulated THP-1 cells Refer to individual Series

ORGANISM(S): Homo sapiens  

SUBMITTER: Lasse Folkersen  

PROVIDER: E-GEOD-32325 | ArrayExpress | 2012-03-07



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Combined chromatin and expression analysis reveals specific regulatory mechanisms within cytokine genes in the macrophage early immune response.

Iglesias Maria Jesus MJ   Reilly Sarah-Jayne SJ   Emanuelsson Olof O   Sennblad Bengt B   Pirmoradian Najafabadi Mohammad M   Folkersen Lasse L   Mälarstig Anders A   Lagergren Jens J   Eriksson Per P   Hamsten Anders A   Odeberg Jacob J  

PloS one 20120227 2

Macrophages play a critical role in innate immunity, and the expression of early response genes orchestrate much of the initial response of the immune system. Macrophages undergo extensive transcriptional reprogramming in response to inflammatory stimuli such as Lipopolysaccharide (LPS).To identify gene transcription regulation patterns involved in early innate immune responses, we used two genome-wide approaches--gene expression profiling and chromatin immunoprecipitation-sequencing (ChIP-seq)  ...[more]

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