Transcriptomics

Dataset Information

3

Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans


ABSTRACT: Resveratrol is a naturally occurring compound that profoundly affects energy metabolism and mitochondrial function and serves as a calorie restriction mimetic, at least in animal models of obesity. Here we treated 10 healthy, obese men with placebo and 150 mg/day resveratrol in a randomized double-blind cross-over study for 30 days. Resveratrol supplementation significantly reduced sleeping- and resting metabolic rate. In muscle, resveratrol activated AMPK, increased SIRT1 and PGC-1alpha protein levels, increased citrate synthase activity, and improved muscle mitochondrial respiration on a fatty acid-derived substrate. Furthermore, resveratrol elevated intramyocellular lipid levels, and decreased intrahepatic lipid content, circulating glucose, triglycerides, alanine-aminotransferase, and inflammation markers. Systolic blood pressure dropped and HOMA index improved after resveratrol. In the postprandial state, adipose tissue lipolysis and plasma fatty acid and glycerol decreased. In conclusion, we demonstrate that 30 days of resveratrol supplementation induces profound metabolic changes in obese subjects, mimicking the effects of calorie restriction. double-blind randomized cross-over study, Expression profiling by microarray

ORGANISM(S): Homo sapiens  

SUBMITTER: Joris Hoeks   Ellen Konings  Riekelt H Houtkooper  Sander Kersten  Vera B Schrauwen-Hinderling  Dongryeol Ryu  Guido Hooiveld  Matthijs K Hesselink  Sophie van der Krieken  Tineke van de Weijer  Esther Moonen-Kornips  Ellen E Blaak  Patrick Schrauwen  Gijs H Goossens  Lena Bilet  Johan Auwerx  Iris Kunz  Silvie Timmers 

PROVIDER: E-GEOD-32357 | ArrayExpress | 2011-11-08

SECONDARY ACCESSION(S): GSE32357PRJNA147241

REPOSITORIES: GEO, ArrayExpress

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Resveratrol is a natural compound that affects energy metabolism and mitochondrial function and serves as a calorie restriction mimetic, at least in animal models of obesity. Here, we treated 11 healthy, obese men with placebo and 150 mg/day resveratrol (resVida) in a randomized double-blind crossover study for 30 days. Resveratrol significantly reduced sleeping and resting metabolic rate. In muscle, resveratrol activated AMPK, increased SIRT1 and PGC-1α protein levels, increased citrate synthas  ...[more]

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