Transcriptomics

Dataset Information

398

The ERI-6/7 helicase acts at the first stage of an siRNA amplification pathway that targets recent gene duplications.


ABSTRACT: To characterize the role of the ERI-6/7 helicase in endogenous small RNA pathways in C. elegans, small RNA populations from null alleles of eri-6 and eri-7, and from mutants of known endogenous RNAi pathway factors, eri-1 and ergo-1, were determined by deep sequencing, and compared to wild type. Small RNA analysis in wild type and eri-1, ergo-1, eri-6 and eri-7 mutant C. elegans strains.

ORGANISM(S): Caenorhabditis elegans  

SUBMITTER: Taiowa Montgomery   Sylvia E Fischer 

PROVIDER: E-GEOD-32366 | ArrayExpress | 2011-09-25

SECONDARY ACCESSION(S): GSE32366SRP008429PRJNA147691

REPOSITORIES: GEO, ArrayExpress, ENA

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Publications

The ERI-6/7 helicase acts at the first stage of an siRNA amplification pathway that targets recent gene duplications.

Fischer Sylvia E J SE   Montgomery Taiowa A TA   Zhang Chi C   Fahlgren Noah N   Breen Peter C PC   Hwang Alexia A   Sullivan Christopher M CM   Carrington James C JC   Ruvkun Gary G  

PLoS genetics 20111110 11


Endogenous small interfering RNAs (siRNAs) are a class of naturally occuring regulatory RNAs found in fungi, plants, and animals. Some endogenous siRNAs are required to silence transposons or function in chromosome segregation; however, the specific roles of most endogenous siRNAs are unclear. The helicase gene eri-6/7 was identified in the nematode Caenorhabditis elegans by the enhanced response to exogenous double-stranded RNAs (dsRNAs) of the null mutant. eri-6/7 encodes a helicase homologous  ...[more]

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