Dataset Information


Transcription profiling of mouse muscle satellite cell-derived myoblasts (MyoD-/-, p53-/-)

ABSTRACT: Muscle satellite cells are a self-renewing pool of stem cells that give rise to daughter myogenic precursor cells in adult skeletal muscle. Published and preliminary data indicated that MyoD and p53 genes are involved in satellite cell differentiation. We would like to know what downstream genes of both transcription factors are affected in satellite cell-derived myoblasts (MyoD-/-, p53 -/-). Experiment Overall Design: this experiment include 3 samples and 25 replicates

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Mus musculus  

SUBMITTER: OGIC Info Ontario Genomics Innovation Centre (OGIC)  

PROVIDER: E-GEOD-3244 | ArrayExpress | 2008-06-12



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MyoD induces myogenic differentiation through cooperation of its NH2- and COOH-terminal regions.

Ishibashi Jeff J   Perry Robert L RL   Asakura Atsushi A   Rudnicki Michael A MA  

The Journal of cell biology 20051101 3

MyoD and Myf5 are basic helix-loop-helix transcription factors that play key but redundant roles in specifying myogenic progenitors during embryogenesis. However, there are functional differences between the two transcription factors that impact myoblast proliferation and differentiation. Target gene activation could be one such difference. We have used microarray and polymerase chain reaction approaches to measure the induction of muscle gene expression by MyoD and Myf5 in an in vitro model. In  ...[more]

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