Transcriptomics

Dataset Information

50

Integrated genomic and gene expression profiling identifies two major gene/genomic circuits operating in urothelial carcinoma (gene expression)


ABSTRACT: Genomic and gene expression profiling identifies two major gene/genomic circuits operating in urothelial carcinoma 131 primary bladder cancer tumor samples were analyzed on Illumina gene expression Bead Arrays.

ORGANISM(S): Homo sapiens  

SUBMITTER: Mattias Hoglund  Martin Lauss   David Lindgren   Mattias Aine   Gottfrid Sjodahl    

PROVIDER: E-GEOD-32548 | ArrayExpress| 2012-06-26

SECONDARY ACCESSION(S): GSE32548PRJNA154427

REPOSITORIES: GEO, ArrayExpress

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Publications

Integrated genomic and gene expression profiling identifies two major genomic circuits in urothelial carcinoma.

Lindgren David D   Sjödahl Gottfrid G   Lauss Martin M   Staaf Johan J   Chebil Gunilla G   Lövgren Kristina K   Gudjonsson Sigurdur S   Liedberg Fredrik F   Patschan Oliver O   Månsson Wiking W   Fernö Mårten M   Höglund Mattias M  

PloS one 20120607 6


Similar to other malignancies, urothelial carcinoma (UC) is characterized by specific recurrent chromosomal aberrations and gene mutations. However, the interconnection between specific genomic alterations, and how patterns of chromosomal alterations adhere to different molecular subgroups of UC, is less clear. We applied tiling resolution array CGH to 146 cases of UC and identified a number of regions harboring recurrent focal genomic amplifications and deletions. Several potential oncogenes we  ...[more]

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