Transcriptomics

Dataset Information

2

MiRNA expression profiling in squamous cell carcinoma (SCC)


ABSTRACT: Despite its prevalence, the molecular basis of squamous cell carcinoma (SCC) remains poorly understood. We recently identified the developmental transcription factor Grhl3 as a potent tumor suppressor of SCC, and demonstrated that targeting of Grhl3 by a miR-21-dependent proto-oncogenic network underpins SCC in humans. Reduced levels of GRHL3 and its target gene PTEN are evident in human skin, and head and neck SCC, associated with increased expression of miR-21, which targets both tumor suppressors. Our data defines the miR-21-GRHL3-PTEN-axis as a critical tumor suppressor pathway in SCC. Total RNA was isolated from two SCC primary tissue samples and their matched normal skin controls.

ORGANISM(S): Homo sapiens  

SUBMITTER: Charbel Darido  

PROVIDER: E-GEOD-32868 | ArrayExpress | 2013-01-18

SECONDARY ACCESSION(S): GSE32868PRJNA146555

REPOSITORIES: GEO, ArrayExpress

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Publications

Targeting of the tumor suppressor GRHL3 by a miR-21-dependent proto-oncogenic network results in PTEN loss and tumorigenesis.

Darido Charbel C   Georgy Smitha R SR   Wilanowski Tomasz T   Dworkin Sebastian S   Auden Alana A   Zhao Quan Q   Rank Gerhard G   Srivastava Seema S   Finlay Moira J MJ   Papenfuss Anthony T AT   Pandolfi Pier Paolo PP   Pearson Richard B RB   Jane Stephen M SM  

Cancer cell 20111101 5


Despite its prevalence, the molecular basis of squamous cell carcinoma (SCC) remains poorly understood. Here, we identify the developmental transcription factor Grhl3 as a potent tumor suppressor of SCC in mice, and demonstrate that targeting of Grhl3 by a miR-21-dependent proto-oncogenic network underpins SCC in humans. Deletion of Grhl3 in adult epidermis evokes loss of expression of PTEN, a direct GRHL3 target, resulting in aggressive SCC induced by activation of PI3K/AKT/mTOR signaling. Rest  ...[more]

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