Transcriptomics

Dataset Information

6

Analysis of the early transcriptome signature of Nipah virus infection in primary endothelial cells


ABSTRACT: Nipah virus (NiV) is a recently emerged zoonotic Paramyxovirus that causes regular outbreaks in East Asia with mortality rate exceeding 75%. Major cellular targets of NiV infection are endothelial cells and neurons. To better understand virus-host interaction, we analysed the transcriptome profile of NiV infection in primary human umbilical vein endothelial cells. We found that NiV infection strongly induces genes involved in interferon response in endothelial cells. Among the top ten upregulated genes, we identified the chemokine CXCL10 (interferon-induced protein 10, IP-10), an important chemoattractant involved in the generation of inflammatory immune response and neurotoxicity. We performed microarray gene expression profiling of NiV infected HUVEC cell (2 replicates) and of uninfected HUVEC cell (2 replicates).

ORGANISM(S): Homo sapiens  

SUBMITTER: Branka HORVAT   HORVAT Branka  Catherine LEGRAS-LACHUER  Cyrille MATHIEU  Vanessa GUILLAUME 

PROVIDER: E-GEOD-32902 | ArrayExpress | 2012-08-24

SECONDARY ACCESSION(S): GSE32902PRJNA146579

REPOSITORIES: GEO, ArrayExpress

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Publications

Lethal Nipah virus infection induces rapid overexpression of CXCL10.

Mathieu Cyrille C   Guillaume Vanessa V   Sabine Amélie A   Ong Kien Chai KC   Wong Kum Thong KT   Legras-Lachuer Catherine C   Horvat Branka B  

PloS one 20120229 2


Nipah virus (NiV) is a recently emerged zoonotic Paramyxovirus that causes regular outbreaks in East Asia with mortality rate exceeding 75%. Major cellular targets of NiV infection are endothelial cells and neurons. To better understand virus-host interaction, we analyzed the transcriptome profile of NiV infection in primary human umbilical vein endothelial cells. We further assessed some of the obtained results by in vitro and in vivo methods in a hamster model and in brain samples from NiV-inf  ...[more]

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