Transcriptomics

Dataset Information

64

MicroRNA-29 in Aortic Dilation: Implications for Aneurysm Formation


ABSTRACT: We compared the aorta of 6-weeks-old mice (young) with 18-months-old mice (old). Using the publicly available tools Sylamer and DIANA-mirExTra, we identified an enrichment for miR-29 binding sites in the 3'UTR of genes downregulated in the aged aortas. We subsequently showed that inhibition of miR-29 in aged mice prevented dilation of the aorta. aortas of 6 week old and 18 month old mice

ORGANISM(S): Mus musculus  

SUBMITTER: Stefanie Dimmeler   Reinier Boon 

PROVIDER: E-GEOD-32937 | ArrayExpress | 2011-10-13

SECONDARY ACCESSION(S): GSE32937PRJNA146571

REPOSITORIES: GEO, ArrayExpress

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Publications


RATIONALE: Aging represents a major risk factor for coronary artery disease and aortic aneurysm formation. MicroRNAs (miRs) have emerged as key regulators of biological processes, but their role in age-associated vascular pathologies is unknown. OBJECTIVE: We aim to identify miRs in the vasculature that are regulated by age and play a role in age-induced vascular pathologies. METHODS AND RESULTS: Expression profiling of aortic tissue of young versus old mice identified several age-associated miR  ...[more]

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