Dataset Information


Sequentially acting Sox transcription factors in neural lineage development [RNA-seq]

ABSTRACT: We report sequential binding but unique functions of different Sox transcription factors during distinct stages of neural differentiation Loss of function experiment for Sox2/Sox3 in neural progenitor cells and gene expression profile for Sox11 expressing (PSA NCAM sorted) early formed neurons.

ORGANISM(S): Mus musculus  

SUBMITTER: Rickard Sandberg   Maria Bergsland  Daniel Ramsköld  Jonas Muhr 

PROVIDER: E-GEOD-33060 | ArrayExpress | 2011-11-01



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Sequentially acting Sox transcription factors in neural lineage development.

Bergsland Maria M   Ramsköld Daniel D   Zaouter Cécile C   Klum Susanne S   Sandberg Rickard R   Muhr Jonas J  

Genes & development 20111115 23

Pluripotent embryonic stem (ES) cells can generate all cell types, but how cell lineages are initially specified and maintained during development remains largely unknown. Different classes of Sox transcription factors are expressed during neurogenesis and have been assigned important roles from early lineage specification to neuronal differentiation. Here we characterize the genome-wide binding for Sox2, Sox3, and Sox11, which have vital functions in ES cells, neural precursor cells (NPCs), and  ...[more]

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