Transcriptomics,Multiomics

Dataset Information

3

Identification of Prognostic Genes for Recurrent Risk Prediction in Triple Negative Breast Cancer Patients in Taiwan


ABSTRACT: Discrepancies in the prognosis of triple negative breast cancer exist between Caucasian and Asian populations. Yet, the gene signature of triple negative breast cancer specifically for Asians has not become available. Therefore, the purpose of this study is to construct a prediction model for recurrence of triple negative breast cancer in Taiwanese patients. Whole genome expression profiling of breast cancers from 185 patients in Taiwan from 1995 to 2008 was performed, and the results were compared to the previously published literature to detect differences between Asian and Western patients. Pathway analysis and Cox proportional hazard models were applied to construct a prediction model for the recurrence of triple negative breast cancer. Most expression data of samples (181/185) were reanalyzed from previous studies already uploaded to GEO (see "reanalysis of" links below). Four additional gene expression profiling data of triple negative breast cancer sample were added to this study.

OTHER RELATED OMICS DATASETS IN: PRJNA149339

ORGANISM(S): Homo sapiens  

SUBMITTER: Lee H Chen   Liang-Chuan Lai  King-Jen Chang  Chuhsing K Hsiao  Pei-Chun Chen  Wen-Hung Kuo  Li-Yun Chang  Mong-Hsun Tsai  Eric Y Chuang  Fon-Jou Hsieh 

PROVIDER: E-GEOD-33095 | ArrayExpress | 2012-02-02

SECONDARY ACCESSION(S): GSE33095PRJNA149339

REPOSITORIES: GEO, ArrayExpress

Dataset's files

Source:
Action DRS
E-GEOD-33095.README.txt Txt
E-GEOD-33095.additional.1.zip Other
E-GEOD-33095.eSet.r Other
E-GEOD-33095.idf.txt Idf
E-GEOD-33095.processed.1.zip Processed
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Publications

Identification of prognostic genes for recurrent risk prediction in triple negative breast cancer patients in Taiwan.

Chen Lee H LH   Kuo Wen-Hung WH   Tsai Mong-Hsun MH   Chen Pei-Chun PC   Hsiao Chuhsing K CK   Chuang Eric Y EY   Chang Li-Yun LY   Hsieh Fon-Jou FJ   Lai Liang-Chuan LC   Chang King-Jen KJ  

PloS one 20111129 11


Discrepancies in the prognosis of triple negative breast cancer exist between Caucasian and Asian populations. Yet, the gene signature of triple negative breast cancer specifically for Asians has not become available. Therefore, the purpose of this study is to construct a prediction model for recurrence of triple negative breast cancer in Taiwanese patients. Whole genome expression profiling of breast cancers from 185 patients in Taiwan from 1995 to 2008 was performed, and the results were compa  ...[more]

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