Transcriptomics

Dataset Information

5

Identification of TDP-43 and FUS mRNA targets and pathways in the cytoplasmic compartment of motorneuronal cells NSC34


ABSTRACT: We performed RNA immunoprecipitation (IP) and microarray (RIP-chip) analyses to identify and compare the biological mRNA targets of two RNA-binding protein (RBP), TDP-43 and FUS, associated to cytoplasmic ribonucleoprotein (RNP) complexes of motoneuronal NSC34 cells with the final aim to unravel their role in mRNA transport, stability, and translation in neuronal cells. To identify the transcripts contained and bound in the isolated RNP complexes, a chip analysis was performed using the recovered mRNAs from triplicate experimantal RIP samples (TDP-43-IP samples, the FUS-IP samples and the control IgG-IP sample).

ORGANISM(S): Mus musculus  

SUBMITTER: Claudia Colombrita   Antonia Ratti  Elisa Onesto 

PROVIDER: E-GEOD-33159 | ArrayExpress | 2011-10-21

SECONDARY ACCESSION(S): GSE33159PRJNA149179

REPOSITORIES: GEO, ArrayExpress

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