Transcriptomics

Dataset Information

4

Analysis of gene expression in Pseudonocardia dioxanivorans strain CB1190 during growth with dioxane, glycolate or pyruvate


ABSTRACT: Analysis of gene expression in Pseudonocardia dioxanivorans strain CB1190 during growth with dioxane, glycolate or pyruvate. Three treatments, based on carbon source used for growth: pyruvate, dioxane and glycolate. Triplicate microarrays (biological replicates) were prepared for each treatment. Pyruvate was used as the reference treatment for subsequent analysis. Gene expression changes were compared pair-wise: dioxane vs. pyruvate, and glycolate vs. pyruvate

ORGANISM(S): Pseudonocardia dioxanivorans CB1190  

SUBMITTER: Ariel Grostern   Chris M Sales  Lisa Alvarez-Cohen 

PROVIDER: E-GEOD-33197 | ArrayExpress | 2012-02-21

SECONDARY ACCESSION(S): GSE33197PRJNA149249

REPOSITORIES: GEO, ArrayExpress

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Publications

Glyoxylate metabolism is a key feature of the metabolic degradation of 1,4-dioxane by Pseudonocardia dioxanivorans strain CB1190.

Grostern Ariel A   Sales Christopher M CM   Zhuang Wei-Qin WQ   Erbilgin Onur O   Alvarez-Cohen Lisa L  

Applied and environmental microbiology 20120210 9


The groundwater contaminant 1,4-dioxane (dioxane) is transformed by several monooxygenase-expressing microorganisms, but only a few of these, including Pseudonocardia dioxanivorans strain CB1190, can metabolize the compound as a sole carbon and energy source. However, nothing is yet known about the genetic basis of dioxane metabolism. In this study, we used a microarray to study differential expression of genes in strain CB1190 grown on dioxane, glycolate (a previously identified intermediate of  ...[more]

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