Transcriptomics

Dataset Information

10

A mouse model of the most aggressive subgroup of human medulloblastoma [Mouse430_2]


ABSTRACT: Mouse models of medulloblastoma are compared to human subgroups through microarray expression and other measures This study contrasts mouse medullablastomas from a range of mouse genetic models. For Shh-type medulloblastoma [dka001-005, 009, 033 and 034] and [dka050-057], spontaneous medulloblastomas from [Cdkn2c-/-; Trp53Fl/Fl; Nestin-Cre] and [Cdkn2c-/-; Ptch1+/-] (Uziel et al.,2005 Genes Dev) were used, respectively. For Myc [dka010-022, 037, 046, 049 and 058-71] and Mycn [dka023-032, 036 and 047] were generated by orthotopic injection of either Myc or Mycn overexpression in Cdkn2c-/-, Trp53-/- cerebellar cells into immunocompromised nude mice. For Wnt-type medulloblastomas [pgr003, 016 and 066], spontaneously developed tumors from CTNNB1+/lox (ex3); BLBP-Cre; Trp53Fl/Fl (Gibson et al., Nature, 2010) were removed for RNA extraction.

ORGANISM(S): Mus musculus  

SUBMITTER: Daisuke Kawauchi   Tamar Uziel  Jerold Rehg  David W Ellison  Giles Robinson  Stanley Pounds  Martine F Roussel  Cuilan Gao  Richard J Gilbertson  Chunxu Qu  Paul Gibson  David Finkelstein 

PROVIDER: E-GEOD-33199 | ArrayExpress | 2012-02-29

SECONDARY ACCESSION(S): GSE33199PRJNA156633

REPOSITORIES: GEO, ArrayExpress

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Publications


Medulloblastomas that display a large cell/anaplastic morphology and overexpress the cellular c-MYC gene are highly aggressive and carry a very poor prognosis. This so-called MYC-subgroup differs in its histopathology, gene expression profile, and clinical behavior from other forms of medulloblastoma. We generated a mouse model of MYC-subgroup medulloblastoma by transducing Trp53-null cerebellar progenitor cells with Myc. The cardinal features of these mouse medulloblastomas closely mimic those  ...[more]

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