Dataset Information


Affymetrix SNP array data for Non-Smoking Female Lung Cancer in Taiwan

ABSTRACT: Genome-Wide Screening of Genomic Alterations and Transcriptional Modulation in Non-Smoking Female Lung Cancer in Taiwan Sixty-one pairs of cancer and normal lung tissue specimens from non-smoking females were collected at National Taiwan University Hospital and Taichung Veterans General Hospital. The selection criteria of clinical specimens depend on pathology report, physical examination and cigarette-smoking history. Surgical lung tissue specimens were immediately snap-frozen in liquid N2 and stored at -80 °C. Surgical specimens would be further processed for RNA and DNA extraction. Only those samples passed quality controls were processed for gene expression profiling analysis and single nucleotide polymorphism (SNP) analysis respectively.

ORGANISM(S): Homo sapiens  

SUBMITTER: Liang-Chuan Lai   Tzu-Pin Lu  Eric Y Chuang 

PROVIDER: E-GEOD-33355 | ArrayExpress | 2012-12-31



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Integrated analyses of copy number variations and gene expression in lung adenocarcinoma.

Lu Tzu-Pin TP   Lai Liang-Chuan LC   Tsai Mong-Hsun MH   Chen Pei-Chun PC   Hsu Chung-Ping CP   Lee Jang-Ming JM   Hsiao Chuhsing Kate CK   Chuang Eric Y EY  

PloS one 20110914 9

Numerous efforts have been made to elucidate the etiology and improve the treatment of lung cancer, but the overall five-year survival rate is still only 15%. Identification of prognostic biomarkers for lung cancer using gene expression microarrays poses a major challenge in that very few overlapping genes have been reported among different studies. To address this issue, we have performed concurrent genome-wide analyses of copy number variation and gene expression to identify genes reproducibly  ...[more]

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