Transcriptomics

Dataset Information

4

NanoString miRNA profiling of peripheral blood mononuclear cells from HIV-1-infected elite suppressors, viremic patients, and uninfected control donors


ABSTRACT: This study used the NanoString nCounter hybridization system and nCounter miRNA expression assays to identify and quantitate circulating cellular miRNAs during HIV-1 elite suppression, active HIV-1 replication, and uninfected status. Blood samples were from eight uninfected controls, seven HIV-1 elite suppressors with undetectable viral load, and six viremic HIV-1-infected patients.

ORGANISM(S): Homo sapiens  

SUBMITTER: Joel N Blankson   Andria K Watson  Janice E Clements  Kenneth W Witwer 

PROVIDER: E-GEOD-33387 | ArrayExpress | 2012-02-22

SECONDARY ACCESSION(S): GSE33387PRJNA154425

REPOSITORIES: GEO, ArrayExpress

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Publications

Relationships of PBMC microRNA expression, plasma viral load, and CD4+ T-cell count in HIV-1-infected elite suppressors and viremic patients.

Witwer Kenneth W KW   Watson Andria K AK   Blankson Joel N JN   Clements Janice E JE  

Retrovirology 20120112


HIV-1-infected elite controllers or suppressors (ES) maintain undetectable viral loads (< 50 copies/mL) without antiretroviral therapy. The mechanisms of suppression are incompletely understood. Modulation of HIV-1 replication by miRNAs has been reported, but the role of small RNAs in ES is unknown. Using samples from a well-characterized ES cohort, untreated viremic patients, and uninfected controls, we explored the PBMC miRNA profile and probed the relationships of miRNA expression, CD4+ T-cel  ...[more]

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