Dataset Information


Open chromatin maps of genetically different yeast strains

ABSTRACT: Open chromatin provides access to a wide spectrum of DNA binding proteins for DNA metabolism processes such as transcription, repair, recombination, and replication. In this regard, open chromatin profiling has been widely used to identify the location of regulatory regions, including promoters, enhancers, insulators, silencers, replication origins, and recombination hotspots. For a quantitative getic analysis of chromatin regulation, we generated open chromatin maps of 100 yeast samples including the parental strains (BY and RM, and two replicates for each) and their descendants by using the FAIRE-seq technique Open chromatin in two parental strains and 94 segregants of their crossing

ORGANISM(S): Saccharomyces cerevisiae  

SUBMITTER: Kwoneel Kim   Jung-Kyoon Choi  KiBaick Lee  kwoneel kim 

PROVIDER: E-GEOD-33466 | ArrayExpress | 2012-11-02



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Chromatin regulation underlies a variety of DNA metabolism processes, including transcription, recombination, repair, and replication. To perform a quantitative genetic analysis of chromatin accessibility, we obtained open chromatin profiles across 96 genetically different yeast strains by FAIRE (formaldehyde-assisted isolation of regulatory elements) assay followed by sequencing. While 5∼10% of open chromatin region (OCRs) were significantly affected by variations in their underlying DNA sequen  ...[more]

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