Dataset Information


MicroRNA expression profiling of small-intestine neuroendocrine tumors and human neuroendocrine tumor cell lines

ABSTRACT: Small intestinal neuroendocrine tumors (SI-NETs) arise from serotonin-producing enterochromaffin cells. SI-NETs are often well-differentiated tumors and most patients have regional or distant metastases at initial presentation. MicroRNAs (miRs) are post-transcriptional regulators which are important in diverse biological processes and can function as tumor suppressor genes or oncogenes. This study aims to identify an exclusive SI-NETs miR profile that may have a critical role in development, diagnosis, prognosis and progression of these malignancies. Five human NET cell lines, one octreotide-treated CNDT2.5 cells, one microdissected normal enterochromaffin cells, three snap-frozen normal ileum specimens and 15 SI-NET specimens at different stage of malignancy, five primary tumors, five mesentery metastases and five liver metastases, were included in this study. Total RNA was hybridized onto Affymetrix GeneChip® miR arrays for genome-wide profiling. Array data summarization, normalization, and quality control were performed using miRNA QC Tool software.

ORGANISM(S): Homo sapiens  

SUBMITTER: Ricardo V Lloyd   Su-Chen Li  Valeria Giandomenico  Ahmed Essaghir  Jean-Baptiste Demoulin  Cécile Martijn  Kjell Öberg 

PROVIDER: E-GEOD-33568 | ArrayExpress | 2013-03-01



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Global microRNA profiling of well-differentiated small intestinal neuroendocrine tumors.

Li Su-Chen SC   Essaghir Ahmed A   Martijn Cécile C   Lloyd Ricardo V RV   Demoulin Jean-Baptiste JB   Oberg Kjell K   Giandomenico Valeria V  

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 20130118 5

Well-differentiated small intestinal neuroendocrine tumors are rare malignancies. They arise from enterochromaffin cells and very little is known about differential microRNA (miRNA) expression. The aim of this study was to identify the miRNA profile of well-differentiated small intestinal neuroendocrine tumors, which may have a critical role in tumor development, progression and potentially develop miRNAs as novel clinical biomarkers. Specimens from two test groups, 24 small intestinal neuroendo  ...[more]

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