Genomics

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Histone Deacetylase 3 is an Epigenomic Brake in Macrophage Alternative Activation (ChIP-Seq)


ABSTRACT: We report the genomic regions enriched in Histone Deacetylase 3 (HDAC3) in mouse bone marrow derived macrophages. Furthermore, we also report the genomic acetylation pattern on Histone 3, Lysine 9 (H3K9) in macrophages with and without HDAC3 and/or treated with Th2 cytokine IL-4. HDAC3 enriched genomic regions in mouse bone marrow dervied macrophages and H3K9Ac enriched genomic regions in wild-type macrophages and macrophages treated with IL-4 and/or deficient in HDAC3.

ORGANISM(S): Mus musculus  

SUBMITTER: Shannon E Mullican   Dan Feng  Mitchell A Lazar  Jonathan Schug  Theresa Alenghat  Logan J Everett  Paul R Giacomin  David Artis  Meera G Nair  David J Steger  Christine A Gaddis 

PROVIDER: E-GEOD-33596 | ArrayExpress | 2011-11-10

SECONDARY ACCESSION(S): GSE33596SRP009249PRJNA154331

REPOSITORIES: GEO, ArrayExpress, ENA

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Publications


Macrophages, a key cellular component of inflammation, become functionally polarized in a signal- and context-specific manner. Th2 cytokines such as interleukin 4 (IL-4) polarize macrophages to a state of alternative activation that limits inflammation and promotes wound healing. Alternative activation is mediated by a transcriptional program that is influenced by epigenomic modifications, including histone acetylation. Here we report that macrophages lacking histone deacetylase 3 (HDAC3) displa  ...[more]

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