Dataset Information


EWS TC-71 cell lines: IGF-1R resistant

ABSTRACT: Ewing's Sarcoma cell lines were made resistant to different IGF-1R drugs to investigate mechanisms and pathways modulated by the resistance. EWS TC-71 cell line was exposed to increasing concentration to three different anti-IGF-1R drugs (HAb AVE1642, TKI NVP-AEW541, HAb CP-751,871, cell lines named respectively as TC/AVE, TC/AEW or TC/CP) for at least six months. Expression profile of resistant cell variants was compared either singularly for each resistance or commonly vs. parental cell line. Two technical replicates for resistant variants and three biological replicated for parental cell were present.

ORGANISM(S): Homo sapiens  

SUBMITTER: Andrea Grilli  

PROVIDER: E-GEOD-34027 | ArrayExpress | 2012-10-03



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Identification of common and distinctive mechanisms of resistance to different anti-IGF-IR agents in Ewing's sarcoma.

Garofalo Cecilia C   Mancarella Caterina C   Grilli Andrea A   Manara Maria Cristina MC   Astolfi Annalisa A   Marino Maria Teresa MT   Conte Alexia A   Sigismund Sara S   Carè Alessandra A   Belfiore Antonino A   Picci Piero P   Scotlandi Katia K  

Molecular endocrinology (Baltimore, Md.) 20120713 9

IGF system contributes significantly to many human malignancies. Targeting IGF-I receptor (IGF-IR) has been reported to be active against several tumors, but particular efficacy was observed only against a minority of Ewing's sarcoma patients. Identification of mechanisms of acquired resistance to anti-IGF-IR agents is mandatory to individualize their use in clinics and optimize cure costs. In this study, we compared gene expression profiles of cells made resistant with three different anti-IGF-  ...[more]

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