Dataset Information


Transcription profiling by array of mouse peritoneal macrophages after treatment with histidine-rich glycoprotein

ABSTRACT: Histidine-rich glycoprotein (HRG) is a 75 kDa heparin-binding plasma protein which has been implicated in regulation of tumor angiogenesis and growth. To exert some of its biological functions, HRG acts on macrophages.This study was performed to assess changes in gene expression in peritoneal macrophages treated with HRG using oligonucleotide microarrays A total of 8 samples were analyzed. Peritoneal macrophages were pooled from 10 wt C57/BL6 mice and treated with recombinant HRG (1ug/ml) for 6 and 24 hours in duplicates

ORGANISM(S): Mus musculus  

SUBMITTER: Sonia Tugues   Lena Claesson-Welsh 

PROVIDER: E-GEOD-34164 | ArrayExpress | 2011-12-06



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Genetic deficiency in plasma protein HRG enhances tumor growth and metastasis by exacerbating immune escape and vessel abnormalization.

Tugues Sònia S   Honjo Satoshi S   König Christian C   Noguer Oriol O   Hedlund Marie M   Botling Johan J   Deschoemaeker Sofie S   Wenes Mathias M   Rolny Charlotte C   Jahnen-Dechent Wilhelm W   Mazzone Massimiliano M   Claesson-Welsh Lena L  

Cancer research 20120228 8

Histidine-rich glycoprotein (HRG) is a 75-kDa heparin-binding plasma protein implicated in the regulation of tumor growth and vascularization. In this study, we show that hrg(-/-) mice challenged with fibrosarcoma or pancreatic carcinoma grow larger tumors with increased metastatic properties. Compared with wild-type mice, fibrosarcomas in hrg(-/-) mice were more hypoxic, necrotic, and less perfused, indicating enhanced vessel abnormalization. HRG deficiency was associated with a suppressed anti  ...[more]

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