Dataset Information


Dual inactivation of Akt and ERK by small molecule TIC10 signals Foxo3a nuclear translocation, TRAIL gene induction and potent anti-tumor effects

ABSTRACT: TIC10-induced transcriptional changes at 48hrs in HCT116 p53-null cells (10uM). Six samples of HCT116 p53-null cells with TIC10 (10uM) or DMSO treatment. Three replicates each.

ORGANISM(S): Homo sapiens  

SUBMITTER: Joshua E Allen   Wafik S El-Deiry 

PROVIDER: E-GEOD-34194 | ArrayExpress | 2013-03-08



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Dual inactivation of Akt and ERK by TIC10 signals Foxo3a nuclear translocation, TRAIL gene induction, and potent antitumor effects.

Allen Joshua E JE   Krigsfeld Gabriel G   Mayes Patrick A PA   Patel Luv L   Dicker David T DT   Patel Akshal S AS   Dolloff Nathan G NG   Messaris Evangelos E   Scata Kimberly A KA   Wang Wenge W   Zhou Jun-Ying JY   Wu Gen Sheng GS   El-Deiry Wafik S WS  

Science translational medicine 20130201 171

Recombinant tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is an antitumor protein that is in clinical trials as a potential anticancer therapy but suffers from drug properties that may limit efficacy such as short serum half-life, stability, cost, and biodistribution, particularly with respect to the brain. To overcome such limitations, we identified TRAIL-inducing compound 10 (TIC10), a potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a  ...[more]

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