Dataset Information


Heme Deficient vs Wild Type in Low Iron

ABSTRACT: Heme Deficient or Wild Type (normal heme) for 6 hrs with iron chelation by BPS. Single Experiment with Probe Reversal 1. GSM78518 (Cy3) vs GSM78519 (Cy5) 2. GSM78520 (Cy3) vs GSM78521 (Cy5)

ORGANISM(S): Saccharomyces cerevisiae  

SUBMITTER: Robert J Crisp   Jerry Kaplan 

PROVIDER: E-GEOD-3470 | ArrayExpress | 2010-06-30



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Recruitment of Tup1p and Cti6p regulates heme-deficient expression of Aft1p target genes.

Crisp Robert J RJ   Adkins Erika M EM   Kimmel Emily E   Kaplan Jerry J  

The EMBO journal 20060126 3

In the budding yeast Saccharomyces cerevisiae, transcription of genes encoding for the high-affinity iron (FET3, FTR1) and copper (CTR1) transporters does not occur in the absence of heme. We show that the Aft1p binding region of the FET3 promoter or the Mac1p binding region of the CTR1 promoter is necessary and sufficient to mediate heme-deficient repression. Transcription is repressed in the absence of heme, and a genetic screen identified Tup1p and Hda1p as being required for transcriptional  ...[more]

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