Transcriptomics

Dataset Information

309

Deep Sequence Analysis of non-small cell lung cancer: Integrated analysis of gene expression, alternative splicing, and single nucleotide variations in lung adenocarcinomas with and without oncogenic KRAS mutations


ABSTRACT: In this manuscript, we have used RNA-Sequencing experiment to obtain and integrate a variety of genomic features in order to identify signaling pathways that are associated to mutant KRAS lung tumors. 8 lung adenocarcinomas with mutant KRAS in lung tumors and 8 lung adenocarcarcinomas without KRAS mutation of which one sample is ran twice for QC purposes.

ORGANISM(S): Homo sapiens  

SUBMITTER: Steven N Hart   Krishna R Kalari  David Rossell  Jean-Pierre Kocher  Asha Nair  Yan W Asmann  Saurabh Baheti  Zhifu Sun  Edith A Perez  Micheal P Walsh  Tiffany R Baker  David N Reisman  High-Seng Chai  Alexey A Leontovich  Jennifer M Carr  Jennifer M Kachergus  Brian M Necela  E A Thompson  Xiaojia Tang  Asif Hossain  Alan P Fields  Curtis S Younkin 

PROVIDER: E-GEOD-34914 | ArrayExpress | 2012-06-07

SECONDARY ACCESSION(S): SRP010166GSE34914PRJNA150161

REPOSITORIES: GEO, ArrayExpress, ENA

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Publications

Deep Sequence Analysis of Non-Small Cell Lung Cancer: Integrated Analysis of Gene Expression, Alternative Splicing, and Single Nucleotide Variations in Lung Adenocarcinomas with and without Oncogenic KRAS Mutations.

Kalari Krishna R KR   Rossell David D   Necela Brian M BM   Asmann Yan W YW   Nair Asha A   Baheti Saurabh S   Kachergus Jennifer M JM   Younkin Curtis S CS   Baker Tiffany T   Carr Jennifer M JM   Tang Xiaojia X   Walsh Michael P MP   Chai High-Seng HS   Sun Zhifu Z   Hart Steven N SN   Leontovich Alexey A AA   Hossain Asif A   Kocher Jean-Pierre JP   Perez Edith A EA   Reisman David N DN   Fields Alan P AP   Thompson E Aubrey EA  

Frontiers in oncology 20120210


KRAS mutations are highly prevalent in non-small cell lung cancer (NSCLC), and tumors harboring these mutations tend to be aggressive and resistant to chemotherapy. We used next-generation sequencing technology to identify pathways that are specifically altered in lung tumors harboring a KRAS mutation. Paired-end RNA-sequencing of 15 primary lung adenocarcinoma tumors (8 harboring mutant KRAS and 7 with wild-type KRAS) were performed. Sequences were mapped to the human genome, and genomic featur  ...[more]

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