Dataset Information


MicroRNA profiling of fetal liver and adult bone marrow pro-B cells

ABSTRACT: We used the NanoString mouse nCounter miRNA expression platform to compare the miRNA expression profiles of pro-B cells sorted from fetal liver and adult bone marrow in order to gain insight into changes in miRNA expression during B cell ontogeny. Fetal liver and adult bone marrow cells were harvested and FACS sorted for pro-B cells (B220+CD43+IgM-veCD19+CD24+). Total RNA was extracted and used for sample preparation and hybridization per manufacturer's instructions.

ORGANISM(S): Mus musculus  

SUBMITTER: Stefan A Muljo   Joan Yuan  Stefan Adi Muljo 

PROVIDER: E-GEOD-35107 | ArrayExpress | 2012-02-17



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Lin28b reprograms adult bone marrow hematopoietic progenitors to mediate fetal-like lymphopoiesis.

Yuan Joan J   Nguyen Cuong K CK   Liu Xiuhuai X   Kanellopoulou Chrysi C   Muljo Stefan A SA  

Science (New York, N.Y.) 20120216 6073

The immune system develops in waves during ontogeny; it is initially populated by cells generated from fetal hematopoietic stem cells (HSCs) and later by cells derived from adult HSCs. Remarkably, the genetic programs that control these two distinct stem cell fates remain poorly understood. We report that Lin28b is specifically expressed in mouse and human fetal liver and thymus, but not in adult bone marrow or thymus. We demonstrate that ectopic expression of Lin28 reprograms hematopoietic stem  ...[more]

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