Dataset Information


Gene expression profiling in wild type and Hif1a-deficient normal and leukemia stem cells

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE35110: Gene expression profiling in WT and Hif1a-/- HSCs GSE35111: Gene expression profiling in BCR/ABL expressing LSCs and BCR/ABL expressing Hif1a-/-LSCs Refer to individual Series

ORGANISM(S): Mus musculus  

SUBMITTER: shaoguang li  

PROVIDER: E-GEOD-35183 | ArrayExpress | 2012-04-03



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HIF1α is required for survival maintenance of chronic myeloid leukemia stem cells.

Zhang Haojian H   Li Huawei H   Xi Hualin S HS   Li Shaoguang S  

Blood 20120124 11

Hypoxia-inducible factor-1α (HIF1α), a master transcriptional regulator of the cellular and systemic hypoxia response, is essential for the maintenance of self-renewal capacity of normal HSCs. It is still unknown whether HIF1α has a role in survival regulation of leukemia stem cells (LSCs) in chronic myeloid leukemia (CML). Using a mouse model of CML, here we report that HIF1α plays a crucial role in survival maintenance of LSCs. Deletion of HIF1α impairs the propagation of CML through impairing  ...[more]

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