Genomics

Dataset Information

302

Genome-wide DNA methylation events in TMPRSS2:ERG fusion negative prostate cancers implicate an EZH2 dependent mechanism with miRNA-26a hypermethylation.


ABSTRACT: Prostate cancer is the second most common cancer among men worldwide. Alterations in the DNA methylation pattern can be one of the leading causes for prostate cancer formation. This study is the first high throughput sequencing study investigating genome-wide DNA methylation patterns in a large cohort of 51 tumor and 53 benign prostate samples using MeDIP-Seq. Comparative analyses identified more than 147,000 cancer-associated epigenetic alterations. Additionally, global methylation patterns demonstrate significant differences based on the TMPRSS2:ERG rearrangement status. We propose the hypermethylation of miRNA-26a as an alternative pathway of ERG rearrangement independent EZH2 activation. The observed increase in differential methylation events in fusion negative tumors can explain the tumorigenic process in the absence of genomic rearrangements. Genomewide examination of methylation profiles in 51 prostate cancer samples

ORGANISM(S): Homo sapiens  

SUBMITTER: Melanie Isau   Markus Graefen  Christoph Plass  Thorsten Schlomm  Michal R Schweiger  Michal-Ruth Schweiger  Guido Sauter  Jan C Brase  Mark Laible  Martin Kerick  Christina Roehr  Axel Fischer  Andrea Wunderlich  Christina Grimm  Andreas Dahl  Ronald Simon  Francesca Demichelis  Rainer Claus  Mark A Rubin  Behnam Sayanjali  Ruprecht Kuner  Bern Timmermann  Stefan T Boerno  Maria Faelth  Holger Sueltmann  Hans Lehrach 

PROVIDER: E-GEOD-35342 | ArrayExpress | 2012-12-06

SECONDARY ACCESSION(S): SRP010586GSE35342PRJNA152715

REPOSITORIES: GEO, ArrayExpress, ENA

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Prostate cancer is the second most common cancer among men worldwide. Alterations in the DNA methylation pattern can be one of the leading causes for prostate cancer formation. This study is the first high-throughput sequencing study investigating genome-wide DNA methylation patterns in a large cohort of 51 tumor and 53 benign prostate samples using methylated DNA immunoprecipitation sequencing. Comparative analyses identified more than 147,000 cancer-associated epigenetic alterations. In additi  ...[more]

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