Genomics

Dataset Information

297

Genome-wide occupancy map of GATA-1 in proliferating and differentiating murine ES cell derived erythroid progenitors (ES-EP)


ABSTRACT: We find GATA-1 occupies 6,600 sites in proliferating erythroid progenitors and 10,600 sites in differentiating progenitors. 80-90% of GATA-1 binds within intragenic or intergenic regions, while <20% of GATA-1 is found within 2kb of TSS. Assaying GATA-1 occupancy in normal erythroid progenitors in both proliferating and differentiating conditions.

ORGANISM(S): Mus musculus  

SUBMITTER: Sandeep Nagaraj Wontakal   Arthur Skoultchi  Sandeep Wontakal 

PROVIDER: E-GEOD-35379 | ArrayExpress | 2012-02-27

SECONDARY ACCESSION(S): GSE35379SRP010616PRJNA156065

REPOSITORIES: GEO, ArrayExpress, ENA

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Publications

A core erythroid transcriptional network is repressed by a master regulator of myelo-lymphoid differentiation.

Wontakal Sandeep N SN   Guo Xingyi X   Smith Cameron C   MacCarthy Thomas T   Bresnick Emery H EH   Bergman Aviv A   Snyder Michael P MP   Weissman Sherman M SM   Zheng Deyou D   Skoultchi Arthur I AI  

Proceedings of the National Academy of Sciences of the United States of America 20120222 10


Two mechanisms that play important roles in cell fate decisions are control of a "core transcriptional network" and repression of alternative transcriptional programs by antagonizing transcription factors. Whether these two mechanisms operate together is not known. Here we report that GATA-1, SCL, and Klf1 form an erythroid core transcriptional network by co-occupying >300 genes. Importantly, we find that PU.1, a negative regulator of terminal erythroid differentiation, is a highly integrated co  ...[more]

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